Publications

A full list of publications can be found here.

Latest Publications

Understanding AAV vector immunogenicity: from particle to patient. Dhungel BP, Winburn I, Pereira CDF, Huang K, Chhabra A, Rasko JEJ. (2024) Theranostics.

SpliceWiz: interactive analysis and visualization of alternative splicing in R. Wong ACH, Wong JJ, Rasko JEJ, Schmitz U. (2023) Brief Bioinform.

High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma. Chu GJ, Linton A, Kao S, Klebe S, Adelstein S, Yeo D, Rasko JEJ, Cooper WA. (2023) Histopathology

Too little, too soon: Japan's experiment in regenerative medicine deregulation. Cyranoski D, Sipp D, Mallik S, Rasko JEJ. (2023) Cell Stem Cell

Accurate isolation and detection of circulating tumor cells using enrichment-free multiparametric high resolution imaging. Yeo D, Kao S, Gupta R, Wahlroos S, Bastian A, Strauss H, Klemm V, Shrestha P, Ramirez AB, Costandy L, Huston R, Gardner BS, Grimison P, Clark JR, Rasko JEJ. (2023) Front. Oncol.

Towards resolution of the intron retention paradox in breast cancer. Shah JS, Milevskiy MJG, Petrova V, Au AYM, Wong JJL, Visvader JE, Schmitz U, Rasko JEJ. (2022) Breast Cancer Res.

Recent advances in cancer fusion transcript detection. Dorney R, Dhungel BP, Rasko JEJ, Hebbard L, Schmitz U. (2022) Brief Bioinform.

Increased chromatin accessibility facilitates intron retention in specific cell differentiation states. Petrova V, Song R; DEEP Consortium, Nordström KJV, Walter J, Wong JJL, Armstrong NJ, Rasko JEJ, Schmitz U. (2022) Nucleic Acids Res.

Illuminating the dark protein-protein interactome. Tabar MS, Parsania C, Chen H, Su XD, Bailey CG, Rasko JEJ. (2022) Cell Reports Methods

Approved gene therapies in Australia: coming to a store near you. Mallik S, Bailey CG, Rasko JEJ. (2022) Intern Med J.

Locoregional delivery of CAR-T cells in the clinic. Sagnella SM, White AL, Yeo D, Saxena P, van Zandwijk N, Rasko JEJ. (2022) Pharmacol Res.

20 Years of Legislation - How Australia Has Responded to the Challenge of Regulating Genetically Modified Organisms in the Clinic. O'Sullivan GM, Philips JG, Mitchell HJ, Dornbusch M, Rasko JEJ (2022) Front. Med.

Mapping oncogenic protein interactions for precision medicine. Tabar MS, Francis H, Yeo D, Bailey CG, Rasko JEJ (2022) Int. J. Cancer.

The next wave of cellular immunotherapies in pancreatic cancer. Yeo D, Giardina C, Saxena P, Rasko JEJ (2022) Mol. Ther. Oncolytics

Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells. Yeo D, Bastian A, Strauss H, Saxena P, Grimison P, Rasko JEJ. (2022) Int. J. Mol. Sci.

Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A. George LA, Monahan PE, Eyster ME, Sullivan SK, Ragni MV, Croteau SE, Rasko JEJ, Recht M, Samelson-Jones BJ, MacDougall A, Jaworski K, Noble R, Curran M, Kuranda K, Mingozzi F, Chang T, Reape KZ, Anguela XM, High KA (2021) N Engl J Med.

The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells. Dhungel BP, Monteuuis G, Giardina C, Tabar MS, Feng Y, Metierre C, Ho S, Nagarajah R, Fontaine ARM, Shah JS, Gokal D, Bailey CG, Schmitz U, Rasko JEJ. (2021) Int. J. Mol. Sci.

Mesenchymal Stromal Cells for the Treatment of Graft Versus Host Disease. Kelly K, Rasko JEJ. (2021) Front. Immunol.

Structure–function relationships explain CTCF zinc finger mutation phenotypes in cancer. Bailey CG, Gupta S, Metierre C, Amarasekera PMS, O'Young P, Kyaw W, Laletin T, Francis H, Semaan C, Sharifi Tabar M, Singh KP, Mullighan CG, Wolkenhauer O, Schmitz U, Rasko JEJ. (2021) Cell Mol Life Sci.

Splice and Dice: Intronic microRNAs, Splicing and Cancer. Wong ACH, Rasko, JEJ. (2021) Biomedicines

Hitting the Bull’s-Eye: Mesothelin’s Role as a Biomarker and Therapeutic Target for Malignant Pleural Mesothelioma. Yeo D, Castelletti L, van Zandwijk N and Rasko JEJ. (2021) Cancers

Unique protein interaction networks define the chromatin remodelling module of the NuRD complex. Tabar MS, Giardina C, Feng Y, Francis H, Sani HM, Low JKK, Mackay JP, Bailey CG, Rasko JEJ. (2021) FEBS J.

CTCF as a regulator of alternative splicing: new tricks for an old player. Alharbi AB, Schmitz U, Bailey CG, Rasko JEJ. (2021) Nucleic Acids Research

Anti-Mesothelin CAR T cell therapy for malignant mesothelioma. Castelletti L, Yeo D, van Zandwijk N and Rasko JEJ. (2021) Biomarker Research

Journey to the Center of the Cell: Tracing the Path of AAV Transduction. Dhungel BP, Bailey CG, Rasko JEJ. (2021) Trends in Molecular Medicine

Selected Publications

Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study. Bloor AJC, Patel A, Griffin JE, Gilleece MH, Radia R, Yeung DT, Drier D, Larson LS, Uenishi GI, Hei D, Kelly K, Slukvin I, Rasko JEJ. (2020) Nature Medicine.

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia. Thompson AA, Walters MC, Kwiatkowski J, Rasko JEJ, Ribeil JA, Hongeng S, Magrin E, Schiller GJ, Payen E, Semeraro M, Moshous D, Lefrere F, Puy H, Bourget P, Magnani A, Caccavelli L, Diana JS, Suarez F, Monpoux F, Brousse V, Poirot C, Brouzes C, Meritet JF, Pondarré C, Beuzard Y, Chrétien S, Lefebvre T, Teachey DT, Anurathapan U, Ho PJ, von Kalle C, Kletzel M, Vichinsky E, Soni S, Veres G, Negre O, Ross RW, Davidson D, Petrusich A, Sandler L, Asmal M, Hermine O, De Montalembert M, Hacein-Bey-Abina S, Blanche S, Leboulch P, Cavazzana M. (2018) N Engl J Med. 378(16):1479-1493

Hemophilia B Gene Therapy with a High Specific Activity Factor IX Variant. George LA, Sullivan SK, Giermasz A, Rasko JEJ, Samelson-Jones BJ, Ducore J, Cuker A, Sullivan LM, Majumdar S, Teitel J, McGuinn KE, Ragni MV, Luk AY, Hui D, Wright JF, Chen Y, Liu Y, Wachte K, Winters A, Tiefenbacher S, Arruda VR, van der Loo JCM, Zelenaia O, Daniel Takefman D, Carr ME, Couto LB, Anguela XM, High KA. (2017) N Engl J Med. 377(23):2215-2227

Genome-wide characterization of the routes to pluripotency. Hussein SMI, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gautheir ME, Le Cao, KA, Kim JL, Mar JC, Shakiba N, Ritchie W, Rasko JEJ, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Rogers IM, Seo JS, Heck AJR, Nagy A. (2014) Nature. 516(7530):198-206

Orchestrated intron retention regulates normal granulocyte differentiation. Wong J J-L, Ritchie W, Ebner O, Selbach M, Wong JWH, Huang Y, Gao D, Pinello N, Gonzalez M, Baidya K, Thoeng A, Khoo T-L, Bailey CG, Holst J, Rasko JEJ. (2013) Cell. 154(3) 583-595

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Holst J, Watson S, Lord MS, Eamegdool SS, Bax DV, Nivison–Smith LB, Kondyurin A, Ma L, Oberhauser AF, Weiss AS, Rasko JEJ. (2010) Nature Biotechnology. 28(10): 1123-6

CD8+ T-cell responses to adeno-associated virus capsid in humans. Mingozzi F, Maus M, Hui D, Sabatino D, Murphy S, Rasko JEJ, Ragni M, Manno C, Sommer J, Jiang H, Pierce G, Ertl H, High KA. (2007) Nature Medicine. 13(4):419-422

Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response. Manno CS, Pierce G, Glader B, Arruda V, Ragni M, Rasko JEJ, Ozelo M, Hoots K, Blatt P, Konkle B, Dake M, Kaye R, Razavi M, Zajko A, Nakai H, Chew A, Leonard D, Wright JF, Sommer J, Tigges M, Sabatino D, Luk A, Jiang H, Couto L, Ertl H, High K, Kay MA. (2006) Nature Medicine. 12(3):342-347

Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter, SLC6A19. Seow HF, Bröer S, Bröer A, Bailey CG, Potter SJ, Cavanaugh JA, Rasko JEJ. (2004) Nature Genetics. 36(9):1003-1007

The RD114 simian type D retrovirus receptor is a neutral amino acid transporter. Rasko JEJ, Battini JL, Gottschalk RJ, Mazo I, Miller AD. (1999) PNAS. 96(5):2129-2134

Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Basser RL, Rasko JEJ, Clarke K, Cebon J, Green MD, Hussein S, Alt C, Menchaca D, Tomita D, Marty J, Fox RM, Begley CG. (1996)The Lancet. 348(9037):1279-81